अमूर्त

Utility of 99mTcO4- static imaging for detecting metastatic lesions in differentiated thyroid cancer

Hongbo Gao, Wei Song, Yuqing Di, Haichun Liu, Yujun Shao, Linlin Ma, Zheng Li, Congjun Jin, Huiliang Xie, Chunyuan Zhao, Lijun Yang, Xiaoyong Zhang, Yonghui Chen

The aim of this study was to evaluate the utility of thyroid static imaging with ^99mTcO₄^- for detecting metastatic lesions following surgery in patients with Differentiated Thyroid Cancer (DTC). A total of 420 consecutive post-total thyroidectomy patients with pathologically diagnosed differentiated thyroid cancer underwent thyroid static imaging with ^99mTcO₄^- before 131I treatment to evaluate the size, location, and function of the residual thyroid. They also underwent 131I whole-body scanning (131IWBS), as well as single-photon emission computed tomography/computed tomography fusion imaging (when necessary), for evaluation of the lesions. The detection rates of thyroid static imaging with ^99mTcO₄^- and 131I-WBS (therapeutic dose) were 83.81% and 98.33%, respectively. The sensitivity of ^99mTcO₄^-  thyroid static imaging was 85.2%, and the rate of detection with both ^99mTcO₄^- static imaging and 131I-WBS was 85.48%. The use of ^99mTcO₄^- thyroid static imaging identified metastatic lesions in 10 patients; thus, the original planned treatment dose and protocol were adjusted in these patients. Based on our findings, we conclude that thyroid static imaging with ^99mTcO₄^- can be used to evaluate the residual thyroid tissue after thyroid carcinoma resection and can identify metastatic lesions, thereby helping to guide the selection of the ¹³¹I treatment dose.