अमूर्त

Pharmacology 2019: Pharmacological Evaluation of Hepatoprotective Activity by Quercetin, Rutin, Silibinin Nanoformulation

Varadhan.R,

Liver is that the largest organ within the physical body . It performs quite 500 metabolic functions. Synthesis, storage, transformation, and clearance of varied chemical compounds and their metabolites are important metabolic functions performed by liver that also make it highly vulnerable to injury caused by any of them. It produces a substance called bile that's excreted outside body through intestinal tract. Bile carries various toxic substances produced within the metabolism that must be timely removed out of the body. Hence, any damage to the liver cells hampers formation of bile and removal of such toxic substances through it. Their accumulation ultimately results in further damage to the liver and whole body. Hepatotoxicants are chemicals that cause liver cell injury. These might be industrial chemicals, natural chemicals, overdose of certain medicinal drugs, and dietary supplements or maybe pesticides. Some drugs may cause liver damage even when used within therapeutic range. Hepatotoxic response is expressed within the characteristic sort of necrobiosis in specific zones of acinar regions in liver. Liver injury in hepatotoxicity may include patterns like zonal necrosis, hepatitis, cholestasis, steatosis, granuloma, vascular lesions, neoplasm and veno-occlusive diseases. These patterns produce to the manifestation of symptoms like jaundice, pruritus, severe abdominal pain, nausea, vomiting, continuous bleeding, skin rashes, generalized itching, weakness, severe fatigue, dark urine, and light-coloured stool. The available synthetic drugs to treat liver disorders during this condition may further worsen the liver damage as they too got to get metabolized in previously damaged liver.