अमूर्त

Investigated the chemotherapy and prognosis of invasive ductal carcinoma patients based on the different molecular phenotypes

Zhu Shengzhang, Li Shanshan, Ou Xia, Zheng Hong, Wang Lingling, Yang Zhihong, Ye Pin

Objective: It was designed to investigate and analyse the survival rate and prognosis of invasive ductal carcinoma patients in different molecular phenotypes groups.

Methods: The data collected from 347 invasive ductal carcinoma patients included symptoms, history and physical examination. Even they were discharged from hospital. Paraffin sections of carcinoma tissues were detected by the tissue chip method. It detected the expression of Estrogen Receptor (ER), Progesterone Receptor (PR), Ki-67, Human Epidermal Growth Factor Receptor 2 (HER-2), B-cell Lymphoma-2 (Bcl-2) and p53 on the tissues sections. Then it was taken systematic analysis.

Results: The incidences of invasive ductal carcinoma concentrated on the middle-age women in the First People’s Hospital of Kunming Medical University from January, 2010 to December 2013. After Pearson chi-square and Spearman Rank sum testing, there were significant differences in the molecular phenotypes among age, tumor size, lymph node metastasis, menopause status and Ki-67 high expression, which could directly impact the prognosis and survival rate. Furthermore, the high level of Bcl-2 and p53 expression in the HER-2 like and triple negative subtypes suggested that they had high risk for tumor cells proliferated rapidly, enhancing invasiveness and poor prognosis.

Conclusion: The Bcl-2 expression closely related to the one and three year survival rate of invasive ductal carcinoma patients, to which should be paid more attention.