जर्नल ऑफ़ बायोमेडिकल इमेजिंग एंड बायोइंजीनियरिंग



Dr.A. Mohamed Sikkander

Micro- and nanotechnologies have been newly combined together, opening new routes for the use of substrate-integrated arrays of microelectrodes (SIAMs) in Neuroscience. Perilously, MEAs offer extensive flexibility in culture preparation, experimental design, and high-through put approaches when compared to predictable electrophysiological techniques. SIAMs have been pioneered in the 70 s, where near the beginning microfabrication techniques were used to obtain devices to be electrochemically united to neurons in vitro and in vivo. The make use of of SIAMs has been established for both recording of bioelectric signals as well as for electrical stimulation of neurons, and shown to profitably enable a non-invasively monitoring of the activity of cultured networks as well as target CNS regions in vivo. Preferably, all materials used in SIAMs fabrication should have far above the ground biocompatibility, excellent electrical properties for a high signal-to-noise ratio of signal detection, transparency for the direct cell analysis, while being lucrative. However, the nearly everyone crucial and desirable feature is the close proximity and cherished mechanical contact between neurons and devices. This is known to lead to dramatic improvements in the electrical coupling between the device and the neurons, defined as the ratio stuck between the maximal signals detected by the device and the maximal transmembrane budding of an excitable cell. The key advantage of SIAM technology is the possibility to increase the spatial decree of conventional electrophysiological techniques, enabling the recordings of simultaneous extracellular signals at spatially distinct sites in a highdensity arrangement.